Induction of apoptosis in plasma cells by B lymphocyte-induced maturation protein-1 knockdown

March 31, 2013

B lymphocyte-induced maturation protein-1 (Blimp-1) is a transcriptional repressor that plays an important role during plasmacytic differentiation and is expressed in normal and transformed plasma cells. We here investigated the importance of continuous Blimp-1 expression. We found that knockdown of Blimp-1 expression by lentiviral vector-delivered short hairpin RNA causes apoptosis in multiple myeloma cell lines and plasmacytoma cells$ indicating that continued expression of Blimp-1 is required for cell survival.

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